Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17113788 | 0.85 | MAPT (0.54) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL9657631 | 0.82 | MAPT (0.56) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL16953181 | 0.79 | BACE1 (0.52) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL226001 | 0.79 | ALDH1A1 (0.51) | MAPTMAPK1KDM4ECYP19A1ALDH1A1 | |
| SCHEMBL28928501 | 0.78 | ALDH1A1 (0.46) | CYP19A1ALDH1A1CYP3A4ALOX15SMN1; SMN2 | |
| SCHEMBL5038570 | 0.76 | MAPT (0.54) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL15872024 | 0.76 | MAPK1 (0.50) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL8552969 | 0.75 | TDP1 (0.47) | MAPTKMT2AMEN1MAPK1NPSR1 | |
| SCHEMBL4069709 | 0.75 | TPMT (0.64) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL9138248 | 0.75 | MAPT (0.57) | MAPTKMT2AMEN1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833630-A4 | NOVEL BENZOPYRAN COMPOUNDS AND METHODS FOR THEIR USE | SUGEN INC (US) | 1998-09-02 | — | — | EP | disclosed |
| EP-0833630-A1 | NOVEL BENZOPYRAN COMPOUNDS AND METHODS FOR THEIR USE | Sugen, Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040110-A1 | NOVEL BENZOPYRAN COMPOUNDS AND METHODS FOR THEIR USE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |