Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407523 | 0.83 | HTR1A (0.40) | HTR1ASLC6A2SLC6A4ADRA2AADRA2B | |
| SCHEMBL7411589 | 0.72 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8552509 | 0.72 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL12375141 | 0.72 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1220344 | 0.72 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1220341 | 0.72 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7415007 | 0.71 | GLA (0.40) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6701385 | 0.71 | SLC6A3 (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8550718 | 0.71 | MEN1 (0.33) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL8551060 | 0.71 | MEN1 (0.33) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846114-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996040682-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1996-12-19 | — | — | WO | disclosed |