Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18073895 | 0.85 | ROCK2 (0.56) | ALDH1A1KDM4ESMN1; SMN2LMNAROCK2 | |
| SCHEMBL8629096 | 0.84 | MAPT (0.55) | ALDH1A1KDM4EGAAHTTLMNA | |
| SCHEMBL8557970 | 0.81 | MAPT (0.40) | ALDH1A1KDM4EGAASMN1; SMN2LMNA | |
| SCHEMBL8624225 | 0.81 | ROCK2 (0.41) | ALDH1A1KDM4EGAAHTTSMN1; SMN2 | |
| SCHEMBL7710536 | 0.80 | HDAC3 (0.46) | SMN1; SMN2ROCK2MAPTIMPDH2TP53 | |
| SCHEMBL8556645 | 0.79 | PARP1 (0.52) | ALDH1A1KDM4EGAAHTTSMN1; SMN2 | |
| SCHEMBL8555826 | 0.77 | KMT2A (0.44) | ALDH1A1KDM4EGAASMN1; SMN2LMNA | |
| SCHEMBL8556446 | 0.76 | SCD (0.41) | ALDH1A1KDM4EGAAHTTSMN1; SMN2 | |
| SCHEMBL7707825 | 0.76 | ROCK2 (0.57) | ALDH1A1KDM4EHTTSMN1; SMN2LMNA | |
| SCHEMBL7422734 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4EGAAPPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |