Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556645 | 0.82 | PARP1 (0.52) | KMT2AMEN1HPGDKDM4EGAA | |
| SCHEMBL7422734 | 0.81 | KDM4E (0.44) | KMT2AMEN1HPGDKDM4EGAA | |
| SCHEMBL7422800 | 0.80 | KMT2A (0.58) | KMT2AMEN1HPGDKDM4EGAA | |
| SCHEMBL18073895 | 0.80 | ROCK2 (0.56) | KDM4EALDH1A1LMNACYP3A4CYP2C9 | |
| SCHEMBL7424222 | 0.80 | HSD17B10 (0.43) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL8556446 | 0.79 | SCD (0.41) | KMT2AMEN1HPGDKDM4EGAA | |
| SCHEMBL7710536 | 0.79 | HDAC3 (0.46) | KMT2AMEN1TP53SMN1; SMN2 | |
| SCHEMBL8629096 | 0.79 | MAPT (0.55) | KMT2AMEN1HPGDKDM4EGAA | |
| SCHEMBL8554262 | 0.78 | ALDH1A1 (0.54) | KMT2AMEN1HPGDKDM4EGAA | |
| SCHEMBL7707705 | 0.78 | SMN1; SMN2 (0.42) | KMT2AMEN1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |