Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 8/20 | 0.42 |
| ▸ | HTR1B | P28222 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553620 | 0.84 | DRD2 (0.46) | HTR1DHTR1BMAPTALOX15L3MBTL1 | |
| SCHEMBL7478444 | 0.84 | HTR1D (0.63) | HTR1DHTR1B | |
| SCHEMBL8550557 | 0.83 | DRD2 (0.43) | HTR1DHTR1BSMN1; SMN2MAPTMCHR1 | |
| SCHEMBL8547605 | 0.82 | RORC (0.45) | HTR1DHTR1B | |
| SCHEMBL7484304 | 0.79 | HTR1D (0.58) | HTR1DHTR1B | |
| SCHEMBL8548534 | 0.79 | DRD2 (0.48) | SMN1; SMN2MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8547656 | 0.77 | KDM4E (0.45) | SMN1; SMN2MAPTL3MBTL1ALDH1A1GAA | |
| SCHEMBL8547532 | 0.76 | BCHE (0.51) | BCHEHTR1DHTR1B | |
| SCHEMBL8547952 | 0.76 | HTR1D (0.45) | BCHEHTR1DHTR1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL8594485 | 0.76 | DRD2 (0.40) | HTR1DHTR1BSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |