Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 9/20 | 0.41 |
| ▸ | HTR1B | P28222 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547605 | 0.85 | RORC (0.45) | DRD2SLC6A4HTR1DHTR1BCHRM4 | |
| SCHEMBL8553701 | 0.83 | BCHE (0.43) | HTR1DHTR1BALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8547656 | 0.82 | KDM4E (0.45) | DRD2SLC6A4NPC1RAB9AKDM4E | |
| SCHEMBL8594485 | 0.81 | DRD2 (0.40) | DRD2SLC6A4HTR1DHTR1BKDM4E | |
| SCHEMBL8548789 | 0.80 | UBE2M (0.39) | DRD2SLC6A4SMN1; SMN2 | |
| SCHEMBL7480587 | 0.80 | HTR1D (0.66) | DRD2HTR1DHTR1B | |
| SCHEMBL8548196 | 0.80 | DRD2 (0.52) | DRD2SLC6A4 | |
| SCHEMBL8551164 | 0.77 | DRD2 (0.53) | DRD2SLC6A4HTR1DHTR1BSMN1; SMN2 | |
| SCHEMBL8552316 | 0.75 | NPC1 (0.54) | DRD2SLC6A4NPC1RAB9AKDM4E | |
| SCHEMBL8552297 | 0.74 | DRD2 (0.48) | DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |