Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664314 | 0.83 | LMNA (0.54) | MEN1KMT2AALDH1A1TSHRAKR1C3 | |
| SCHEMBL2534838 | 0.82 | LMNA (0.61) | MEN1KMT2AALDH1A1TSHRNR1I2 | |
| SCHEMBL7625514 | 0.82 | MCL1 (0.43) | MEN1KMT2AALDH1A1TSHRAKR1C3 | |
| SCHEMBL10187523 | 0.80 | MCL1 (0.50) | KDM1AMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL18192045 | 0.80 | MCL1 (0.50) | KDM1AMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL14604980 | 0.80 | MCL1 (0.50) | KDM1AMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9764639 | 0.78 | CYP3A4 (0.55) | MEN1KMT2AALDH1A1TSHRAKR1C3 | |
| SCHEMBL14690678 | 0.77 | KEAP1 (0.48) | ALDH1A1LMNAMCL1TDP1CYP3A4 | |
| SCHEMBL10492917 | 0.77 | MCL1 (0.40) | MEN1KMT2AALDH1A1TSHRAKR1C3 | |
| SCHEMBL7659594 | 0.76 | MCL1 (0.46) | KDM1AMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0879233-A1 | CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-25 | — | — | EP | disclosed |
| WO-1997028153-A1 | CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-07 | — | — | WO | disclosed |