SCHEMBL8553722

SCHEMBL8553722

Cc1nc(CCC2CCNCC2)sc1C(=O)N1CCN(CC(=O)O)CC1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 4/20 0.37
GAA P10253 2/20 0.34
TSHR P16473 1/20 0.34
ITGB3 P05106 4/20 0.34
ITGA2B P08514 4/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
SIGLEC9 Q9Y336 1/20 0.33
CNR1 P21554 1/20 0.33
CACNA2D1 P54289 1/20 0.33
CACNA1B Q00975 1/20 0.33
CACNB1 Q02641 1/20 0.33
TPSAB1 Q15661 2/20 0.32
TPSD1 Q9BZJ3 2/20 0.32
TPSG1 Q9NRR2 2/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549523 0.89 HTR2C (0.35) HTR2CGAATSHRITGB3ITGA2B
Hydrochloric Acid SCHEMBL8627559 0.69 LMNA (0.43) GAATSHRITGB3ITGA2BALDH1A1
Hydrochloric Acid SCHEMBL8551751 0.69 LMNA (0.43) GAATSHRITGB3ITGA2BALDH1A1
SCHEMBL8554046 0.67 LMNA (0.42) GAAITGB3ITGA2BALDH1A1
SCHEMBL8554049 0.67 LMNA (0.42) GAAITGB3ITGA2BALDH1A1
SCHEMBL8627057 0.66 ITGB3 (0.35) ITGB3ITGA2BCACNA2D1CACNA1BCACNB1
Hydrochloric Acid SCHEMBL8549999 0.66 LMNA (0.41) GAAITGB3ITGA2BALDH1A1
SCHEMBL7285155 0.64 ITGB3 (0.55) ITGB3ITGA2BTPSAB1TPSD1TPSG1
Bromide SCHEMBL8554036 0.64 GSK3B (0.42)
SCHEMBL8625194 0.62 KDM4C (0.34) HTR2CGAAALDH1A1HPGDCACNA2D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817677-A ANTITHROMBOSIS AGENTS DR. KARL THOMAE GMBH (DE) 1998-10-06 US disclosed
EP-0858457-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM Dr. Karl Thomae GmbH (DE) 1998-08-19 EP disclosed
WO-1997015567-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM DR. KARL THOMAE GMBH (DE) 1997-05-01 WO disclosed