Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.69 |
| ▸ | HTR1A | P08908 | 5/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.69 |
| ▸ | DRD4 | P21917 | 2/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | HTR6 | P50406 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790948 | 0.87 | DRD2 (0.72) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL8870806 | 0.87 | HTR1A (0.59) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL791945 | 0.86 | DRD2 (0.70) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL9229535 | 0.85 | SLC6A4 (0.64) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL8553783 | 0.85 | HTR1A (0.81) | DRD2HTR1ASLC6A4HTR2A | |
| SCHEMBL10577566 | 0.84 | HTR1A (0.61) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL15064476 | 0.84 | SLC6A4 (0.69) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL7136564 | 0.83 | DRD2 (0.67) | DRD2HTR1ASLC6A4DRD4DRD3 | |
| SCHEMBL8555542 | 0.83 | TDP1 (0.71) | DRD2HTR1ADRD4DRD3CYP1A2 | |
| SCHEMBL8556346 | 0.83 | SIGMAR1 (0.74) | DRD2HTR1ASLC6A4DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |