Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 5/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 7/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | C5 | P01031 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556036 | 0.92 | NR4A2 (0.43) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL8561919 | 0.91 | NR4A2 (0.41) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL8558559 | 0.89 | NR4A2 (0.45) | PPARDNR4A2GPBAR1 | |
| SCHEMBL8557612 | 0.88 | RXRA (0.43) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL8555127 | 0.88 | NPC1 (0.41) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL7505354 | 0.85 | CA12 (0.52) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL7510837 | 0.85 | CA12 (0.52) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL8555570 | 0.84 | POLB (0.43) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL8553646 | 0.82 | CA12 (0.44) | PPARDNR4A2RXRARXRBRXRG | |
| SCHEMBL8553922 | 0.82 | NR4A2 (0.45) | PPARDNR4A2RXRARXRBGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |