Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 10/20 | 0.43 |
| ▸ | RXRA | P19793 | 7/20 | 0.42 |
| ▸ | RXRB | P28702 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558002 | 0.92 | CA12 (0.43) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8560970 | 0.92 | PTGS1 (0.43) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8557269 | 0.92 | NR4A2 (0.44) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8561919 | 0.91 | NR4A2 (0.41) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8556036 | 0.91 | NR4A2 (0.43) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8559017 | 0.90 | KMT2A (0.46) | NR4A2RXRARXRBSMN1; SMN2POLB | |
| SCHEMBL8556746 | 0.90 | GRM5 (0.41) | NR4A2RXRARXRBPPARDRXRG | |
| SCHEMBL8553922 | 0.88 | NR4A2 (0.45) | NR4A2RXRARXRBNPC1RAB9A | |
| SCHEMBL8555996 | 0.86 | RXRA (0.43) | NR4A2RXRARXRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8555242 | 0.86 | NR4A2 (0.49) | CA12CA1CA2CA9NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |