Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | PTAFR | P25105 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477516 | 0.86 | CYP11B2 (0.51) | CYP11B2CYP11B1PTAFRCYP19A1CYP17A1 | |
| SCHEMBL8484267 | 0.81 | CYP11B2 (0.47) | CYP11B2CYP11B1PTAFRCYP19A1CYP17A1 | |
| SCHEMBL8481502 | 0.76 | CYP11B1 (0.40) | CYP11B2CYP11B1PTAFRCYP19A1CYP17A1 | |
| SCHEMBL10695136 | 0.76 | PTAFR (0.51) | PTAFR | |
| SCHEMBL5016747 | 0.74 | CHRNA7 (0.57) | — | |
| SCHEMBL10696517 | 0.73 | KMT2A (0.49) | CYP11B2CYP11B1PTAFRCYP19A1CYP2C9 | |
| SCHEMBL8479969 | 0.72 | CYP51A1 (0.50) | CYP11B2CYP11B1CYP19A1CYP17A1IDO1 | |
| SCHEMBL5752462 | 0.72 | CYP11B2 (0.55) | ABCB11CYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL8479757 | 0.72 | POLB (0.52) | NAMPTSMN1; SMN2 | |
| SCHEMBL8479585 | 0.72 | CYP1A1 (0.59) | ABCB11NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |