Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 3/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477516 | 0.88 | CYP11B2 (0.51) | CYP11B1CYP11B2CYP19A1CYP2C9NAMPT | |
| SCHEMBL8476422 | 0.84 | LMNA (0.45) | CYP11B1CYP11B2CYP19A1CYP2C9NAMPT | |
| SCHEMBL8484267 | 0.83 | CYP11B2 (0.47) | CYP11B1CYP11B2CYP19A1CYP2C9HTR1A | |
| SCHEMBL8481712 | 0.82 | PTAFR (0.40) | CYP11B1CYP11B2CYP19A1CYP2C9NAMPT | |
| SCHEMBL8481721 | 0.82 | PTAFR (0.40) | CYP11B1CYP11B2CYP19A1CYP2C9NAMPT | |
| SCHEMBL8479969 | 0.81 | CYP51A1 (0.50) | CYP11B1CYP11B2CYP19A1NAMPTMEN1 | |
| SCHEMBL8479757 | 0.79 | POLB (0.52) | NAMPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL8073554 | 0.78 | TBXAS1 (0.49) | NAMPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7954714 | 0.78 | TBXAS1 (0.49) | NAMPTMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8482036 | 0.78 | CYP19A1 (0.47) | CYP11B1CYP11B2CYP19A1CYP51A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |