Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | ATF4 | P18848 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7620879 | 0.89 | SIGMAR1 (0.60) | ANO1LMNAHPGDSIGMAR1P2RX7 | |
| Bicarbonate SCHEMBL7621065 | 0.88 | ALPL (0.47) | ANO1LMNAHPGDP2RX7NPC1 | |
| Bicarbonate SCHEMBL8558897 | 0.88 | LMNA (0.50) | LMNAHPGDSMN1; SMN2SIGMAR1P2RX7 | |
| Bicarbonate SCHEMBL8557459 | 0.87 | HPGD (0.62) | ANO1LMNAHPGDSMN1; SMN2SIGMAR1 | |
| Bicarbonate SCHEMBL8557002 | 0.86 | LMNA (0.60) | ANO1LMNAHPGDSMN1; SMN2SIGMAR1 | |
| Bicarbonate SCHEMBL8553268 | 0.86 | LMNA (0.60) | ANO1LMNAHPGDSMN1; SMN2SIGMAR1 | |
| Bicarbonate SCHEMBL8554916 | 0.85 | LMNA (0.48) | LMNAHPGDSMN1; SMN2SIGMAR1P2RX7 | |
| Bicarbonate SCHEMBL4435083 | 0.85 | MEN1 (0.55) | ANO1LMNAHPGDSMN1; SMN2SIGMAR1 | |
| Bicarbonate SCHEMBL8558449 | 0.84 | LMNA (0.50) | LMNAHPGDSMN1; SMN2SIGMAR1P2RX7 | |
| Bicarbonate SCHEMBL8555003 | 0.84 | LMNA (0.47) | ANO1LMNAHPGDSMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |