Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8553268 | 0.99 | LMNA (0.60) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8557002 | 0.99 | LMNA (0.60) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8558897 | 0.90 | LMNA (0.50) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8553237 | 0.88 | LMNA (0.49) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8554252 | 0.87 | ANO1 (0.52) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8554916 | 0.87 | LMNA (0.48) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8558449 | 0.86 | LMNA (0.50) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8555003 | 0.86 | LMNA (0.47) | HPGDLMNASMN1; SMN2POLBEPHX2 | |
| Bicarbonate SCHEMBL8555858 | 0.85 | TAS1R3 (0.54) | HPGDLMNASMN1; SMN2TSHRTDP1 | |
| Bicarbonate SCHEMBL8554265 | 0.84 | LMNA (0.45) | HPGDLMNASMN1; SMN2POLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |