Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 8/20 | 0.42 |
| ▸ | CDK2 | P24941 | 8/20 | 0.42 |
| ▸ | CDK4 | P11802 | 5/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554283 | 0.76 | ABL1 (0.69) | ABL1PDGFRBBCRSRCPDGFRA | |
| SCHEMBL7464447 | 0.74 | PIK3CA (0.62) | CDK1CCNB1DYRK1AABL1BCR | |
| SCHEMBL7471212 | 0.71 | CDK5 (0.47) | CCNT1CDK9ABL1BCRSRC | |
| SCHEMBL7463567 | 0.69 | SRC (0.56) | ABL1BCRSRCGSK3BCDK2 | |
| SCHEMBL7469251 | 0.68 | IKBKB (0.52) | CDK1CDK9CDK7ABL1BCR | |
| SCHEMBL7469678 | 0.68 | SYK (0.56) | CDK2CDK4TLR8 | |
| SCHEMBL25060953 | 0.67 | NTRK1 (0.43) | — | |
| SCHEMBL29845711 | 0.67 | RAB9A (0.55) | — | |
| SCHEMBL23413191 | 0.67 | RAB9A (0.55) | — | |
| SCHEMBL3812955 | 0.66 | CDK1 (1.00) | CCNT1CDK1CCNB1CDK9DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0453731-A2 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1991-10-30 | — | — | EP | claimed |