SCHEMBL8554348

SCHEMBL8554348

COC(=O)c1ccccc1NC(=O)c1ccc(OC)nc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.61
CYP1A2 P05177 2/20 0.61
CYP2C19 P33261 2/20 0.61
CYP2D6 P10635 1/20 0.61
KMT2A Q03164 4/20 0.60
MAPT P10636 3/20 0.60
MEN1 O00255 3/20 0.60
GAA P10253 2/20 0.60
POLB P06746 2/20 0.60
LMNA P02545 2/20 0.60
HSD17B10 Q99714 2/20 0.60
KDM4E B2RXH2 2/20 0.60
MAPK1 P28482 3/20 0.57
APOBEC3A P31941 1/20 0.56
APOBEC3G Q9HC16 1/20 0.56
AHR P35869 1/20 0.55
HPGD P15428 1/20 0.55
MAPK10 P53779 1/20 0.55
ELANE P08246 1/20 0.54
PRTN3 P24158 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8564208 0.90 CHEK1 (0.61) KMT2AMAPTMEN1GAAPOLB
SCHEMBL8560123 0.88 CHEK1 (0.60) KMT2AMAPTMEN1GAAPOLB
SCHEMBL5584774 0.87 MEN1 (0.53) TSHRCYP1A2CYP2C19CYP2D6KMT2A
SCHEMBL8557467 0.87 LMNA (0.53) TSHRCYP1A2CYP2C19CYP2D6KMT2A
SCHEMBL8560118 0.87 MEN1 (0.53) TSHRCYP1A2CYP2C19CYP2D6KMT2A
SCHEMBL6347621 0.86 ELANE (0.57) TSHRCYP1A2CYP2C19CYP2D6KMT2A
SCHEMBL5584406 0.84 PKM (0.52) TSHRKMT2AMAPTMEN1GAA
SCHEMBL5584408 0.84 MEN1 (0.50) TSHRCYP1A2CYP2C19CYP2D6KMT2A
SCHEMBL8908002 0.81 F10 (0.48) KMT2AMAPTMEN1GAAPOLB
SCHEMBL8907998 0.81 F10 (0.48) KMT2AMAPTMEN1GAAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0750611-B1 ANILIDE DERIVATIVES AS FUNGICIDES AGREVO UK LTD (GB) 1998-07-08 EP disclosed
US-5756524-A APPLYING TO COMBAT CYTOPATHOGENIC FUNGI AGREVO UK LIMITED (GB) 1998-05-26 US disclosed
EP-0750611-A1 ANILIDE DERIVATIVES AS FUNGICIDES AgrEvo UK Limited (GB) 1997-01-02 EP disclosed
WO-1995025723-A1 ANILIDE DERIVATIVES AS FUNGICIDES AGREVO UK LIMITED (GB) 1995-09-28 WO disclosed