SCHEMBL8557467

SCHEMBL8557467

COC(=O)c1ccccc1NC(=S)c1ccc(OC)nc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.53
MAPT P10636 8/20 0.53
KDM4E B2RXH2 8/20 0.53
ALDH1A1 P00352 7/20 0.53
KMT2A Q03164 6/20 0.53
ALOX12 P18054 4/20 0.53
MEN1 O00255 3/20 0.53
HPGD P15428 2/20 0.53
GAA P10253 2/20 0.49
POLB P06746 1/20 0.49
TSHR P16473 3/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C19 P33261 1/20 0.49
HSD17B10 Q99714 3/20 0.48
MAPK1 P28482 1/20 0.48
HTT P42858 1/20 0.47
NNMT P40261 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8557845 0.90 KDM4E (0.52) LMNAMAPTKDM4EALDH1A1KMT2A
SCHEMBL8554348 0.87 TSHR (0.61) LMNAMAPTKDM4EALDH1A1KMT2A
SCHEMBL8559131 0.87 ALDH1A1 (0.47) LMNAMAPTKDM4EALDH1A1KMT2A
SCHEMBL8559233 0.85 LMNA (0.56) LMNAMAPTKDM4EALDH1A1KMT2A
SCHEMBL8561509 0.80 MAPT (0.51) LMNAMAPTKDM4EALDH1A1KMT2A
SCHEMBL8564208 0.77 CHEK1 (0.61) LMNAMAPTALDH1A1KMT2AMEN1
SCHEMBL8560123 0.76 CHEK1 (0.60) LMNAMAPTALDH1A1KMT2AMEN1
SCHEMBL5584774 0.75 MEN1 (0.53) LMNAMAPTALDH1A1KMT2AMEN1
SCHEMBL8560118 0.75 MEN1 (0.53) LMNAMAPTKDM4EKMT2AMEN1
SCHEMBL65277 0.74 NNMT (0.68) LMNAMAPTKDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756524-A APPLYING TO COMBAT CYTOPATHOGENIC FUNGI AGREVO UK LIMITED (GB) 1998-05-26 US disclosed
EP-0750611-A1 ANILIDE DERIVATIVES AS FUNGICIDES AgrEvo UK Limited (GB) 1997-01-02 EP disclosed
WO-1995025723-A1 ANILIDE DERIVATIVES AS FUNGICIDES AGREVO UK LIMITED (GB) 1995-09-28 WO disclosed