Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10855469 | 0.79 | CYP3A4 (0.41) | MAOAALDH1A1TSHRCYP3A4MAPK1 | |
| SCHEMBL8552180 | 0.79 | LMNA (0.51) | MAOAMAOBALDH1A1L3MBTL1CES2 | |
| SCHEMBL58239 | 0.78 | MAOA (0.47) | MAOAMAOBALDH1A1TSHRMAPK1 | |
| SCHEMBL8552972 | 0.77 | HPGD (0.47) | MAOAMAOBALDH1A1HPGDMAPT | |
| SCHEMBL22561057 | 0.76 | ESR2 (0.45) | ALDH1A1TSHRCYP3A4MAPK1ALOX15 | |
| SCHEMBL29221764 | 0.76 | CA1 (0.53) | ALDH1A1TSHRL3MBTL1HPGDMAPT | |
| SCHEMBL2015853 | 0.76 | MAOA (0.55) | MAOAMAOBALDH1A1TSHRL3MBTL1 | |
| SCHEMBL1154812 | 0.75 | GSK3B (0.57) | ALDH1A1L3MBTL1HPGDCES2CES1 | |
| SCHEMBL31423426 | 0.75 | MAOA (0.46) | MAOAMAOBALDH1A1TSHRL3MBTL1 | |
| SCHEMBL19941901 | 0.73 | RAB9A (0.41) | MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861245-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997019073-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |