Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085228 | 0.81 | NR1I2 (0.63) | LMNANR1I2MAPTMAOAMAOB | |
| SCHEMBL14407542 | 0.81 | NR1I2 (0.52) | LMNANR1I2MAPTMAOAMAOB | |
| SCHEMBL22561008 | 0.81 | KDM4E (0.49) | LMNAL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL16795750 | 0.79 | MAPT (0.50) | LMNANR1I2MAPTMAOAMAOB | |
| SCHEMBL13962133 | 0.79 | CA1 (0.50) | NR1I2MAPTMAOAMAOBCA1 | |
| SCHEMBL8554384 | 0.79 | MAOA (0.50) | LMNAL3MBTL1MAPTMAOAMAOB | |
| SCHEMBL989934 | 0.79 | GSK3B (0.60) | LMNANR1I2MAPTMAOAMAOB | |
| SCHEMBL10855469 | 0.79 | CYP3A4 (0.41) | LMNAMAPTMAOAALDH1A1PRSS1 | |
| SCHEMBL8557285 | 0.77 | CES2 (0.55) | LMNAMAOAMAOBCES2CES1 | |
| SCHEMBL20446944 | 0.77 | CA1 (0.65) | L3MBTL1MAPTCA1CA2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861245-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997019073-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |