Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825041 | 0.85 | ALDH1A1 (0.48) | ALDH1A1GPR35MAPTKMT2AMEN1 | |
| SCHEMBL16234805 | 0.80 | MEN1 (0.54) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL6213726 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL7520916 | 0.78 | KMT2A (0.55) | ALDH1A1GPR35MAPTKMT2AMEN1 | |
| SCHEMBL9869407 | 0.74 | ADRA2A (0.44) | ALDH1A1GPR35MAPTKMT2AMEN1 | |
| SCHEMBL7801883 | 0.74 | NPC1 (0.53) | ALDH1A1MAPTRAB9A | |
| SCHEMBL11879315 | 0.73 | ALDH1A1 (0.52) | ALDH1A1GPR35MAPTKMT2AMEN1 | |
| SCHEMBL27501452 | 0.73 | ALDH1A1 (0.52) | ALDH1A1GPR35MAPTKMT2AMEN1 | |
| SCHEMBL10913204 | 0.73 | MAPT (0.48) | ALDH1A1MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL10913206 | 0.73 | MAPT (0.48) | ALDH1A1MAPTKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582164-B1 | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles | BRISTOL MYERS SQUIBB CO (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5382584-A | Antiischemic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-01-17 | — | — | US | disclosed |
| CN-1085216-A | Have the diphenyl-oxazole, thiazole and the imdazole derivatives that suppress the adenosine resorption | BRISTOL MYERS SQUIBB CO (US) | 1994-04-13 | — | — | CN | disclosed |
| EP-0582164-A1 | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles | Bristol-Myers Squibb Company (US) | 1994-02-09 | — | — | EP | disclosed |