Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 4/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.34 |
| ▸ | RELA | Q04206 | 4/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220507 | 0.84 | GRM2 (0.31) | IKBKBGRM2 | |
| SCHEMBL8130792 | 0.83 | JUN (0.37) | JUNNFKB1NFKB2RELAACE2 | |
| SCHEMBL3032750 | 0.81 | JUN (0.39) | JUNNFKB1NFKB2RELAACE2 | |
| SCHEMBL8557880 | 0.79 | BCHE (0.31) | — | |
| SCHEMBL8557193 | 0.78 | HTR6 (0.35) | — | |
| SCHEMBL8555364 | 0.75 | HCAR1 (0.32) | — | |
| SCHEMBL8556186 | 0.75 | — | — | |
| SCHEMBL8114995 | 0.73 | — | — | |
| SCHEMBL8124478 | 0.73 | — | — | |
| SCHEMBL9556590 | 0.71 | JUN (0.43) | JUNNFKB1NFKB2RELAACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | claimed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | claimed |
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |