Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556864 | 0.91 | SCN9A (0.40) | SCN9AF10ADORA2AADORA1HPGD | |
| SCHEMBL8557473 | 0.84 | NR4A2 (0.44) | SCN9AHPGDALDH1A1 | |
| SCHEMBL8556213 | 0.84 | PTGS1 (0.40) | HPGDALDH1A1CA2CA9 | |
| SCHEMBL8559346 | 0.83 | NR4A2 (0.48) | ALDH1A1GAACA2CA9 | |
| SCHEMBL7503097 | 0.83 | CA2 (0.48) | ALDH1A1CA2CA9 | |
| SCHEMBL8555763 | 0.81 | RXRA (0.46) | SCN9AHPGDALDH1A1CA2CA9 | |
| SCHEMBL8556639 | 0.81 | FAAH (0.36) | SCN9AALDH1A1GAACA2CA9 | |
| SCHEMBL8556259 | 0.80 | NPC1 (0.41) | SCN9AHPGDALDH1A1 | |
| SCHEMBL8556768 | 0.79 | NR4A2 (0.45) | HPGDALDH1A1 | |
| SCHEMBL8560576 | 0.79 | RXRA (0.46) | SCN9AF10HPGDALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |