Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 5/20 | 0.39 |
| ▸ | EDNRA | P25101 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558261 | 0.82 | HSD11B1 (0.44) | TSHRHSD11B1MEN1MAPTKMT2A | |
| SCHEMBL8555072 | 0.82 | SLC40A1 (0.45) | TSHRHSD11B1MEN1MAPTKMT2A | |
| SCHEMBL8556764 | 0.81 | MAPT (0.54) | TSHRHSD11B1MEN1MAPTKMT2A | |
| SCHEMBL8558669 | 0.81 | TSHR (0.41) | TSHRHSD11B1CCNE2CCNE1CDK2 | |
| SCHEMBL8560795 | 0.80 | EDNRB (0.43) | TSHRHSD11B1MEN1MAPTKMT2A | |
| SCHEMBL8557632 | 0.80 | NR4A2 (0.57) | TSHRHSD11B1MEN1MAPTKMT2A | |
| SCHEMBL8553642 | 0.78 | AR (0.46) | TSHRHSD11B1MEN1MAPTKMT2A | |
| SCHEMBL8557447 | 0.78 | RXRA (0.59) | TSHRKDM4EHPGDCYP2C19LMNA | |
| SCHEMBL8561174 | 0.76 | TSHR (0.44) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5694177 | 0.75 | EDNRB (0.51) | TSHRHSD11B1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |