Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314801 | 0.78 | MEN1 (0.45) | HSD17B10NPSR1KDM4EGAAALDH1A1 | |
| SCHEMBL4437207 | 0.76 | NPSR1 (0.41) | GRIA1GRIA3GRIA2GRIA4FFAR4 | |
| SCHEMBL84167 | 0.68 | GLA (0.35) | GRIA1GRIA3GRIA2GRIA4KDM4E | |
| SCHEMBL17755880 | 0.67 | MITF (0.38) | FFAR4NPSR1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL12500526 | 0.67 | P2RX7 (0.44) | GAAALDH1A1L3MBTL1ATMTDP1 | |
| SCHEMBL13319961 | 0.67 | GRIA1 (0.61) | GRIA1GRIA3GRIA2GRIA4ALDH1A1 | |
| SCHEMBL11628784 | 0.67 | TDP1 (0.40) | NPSR1KDM4EGAAALDH1A1L3MBTL1 | |
| SCHEMBL9145600 | 0.66 | GRIA1 (0.38) | GRIA1GRIA3GRIA2GRIA4GAA | |
| SCHEMBL8609634 | 0.66 | GRIA1 (0.40) | GRIA1GRIA3GRIA2GRIA4GAA | |
| SCHEMBL28830916 | 0.64 | NPSR1 (0.50) | HSD17B10NPSR1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859763-A1 | DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | Bearsden Bio, Inc. (US) | 1998-08-26 | — | — | EP | claimed |
| WO-1998056752-A1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1998-12-17 | — | — | WO | disclosed |