Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | RXRB | P28702 | 7/20 | 0.49 |
| ▸ | RXRG | P48443 | 4/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560137 | 0.92 | RXRA (0.49) | RXRARXRBRXRGNR4A2RAB9A | |
| SCHEMBL8560360 | 0.92 | RXRA (0.44) | RXRARXRBRXRGNR4A2RAB9A | |
| SCHEMBL8556768 | 0.89 | NR4A2 (0.45) | RXRARXRBRXRGNR4A2MAPK1 | |
| SCHEMBL8560532 | 0.88 | RXRA (0.46) | RXRARXRBRXRGNR4A2CA1 | |
| SCHEMBL8561401 | 0.88 | MAOB (0.41) | RXRARXRBRXRGNR4A2RAB9A | |
| SCHEMBL8556529 | 0.88 | RXRA (0.40) | RXRARXRBRXRGNR4A2F10 | |
| SCHEMBL8555143 | 0.88 | RXRA (0.49) | RXRARXRBRXRGNR4A2RAB9A | |
| SCHEMBL8556294 | 0.87 | RXRA (0.49) | RXRARXRBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8554839 | 0.85 | RXRA (0.38) | RXRARXRBRXRGNR4A2RAB9A | |
| SCHEMBL8556756 | 0.85 | NPC1 (0.39) | RXRARXRBRXRGNR4A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |