Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | RXRB | P28702 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.40 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558256 | 0.92 | MAOB (0.41) | MAOBRXRARXRBNR4A2GPR174 | |
| SCHEMBL8557215 | 0.91 | PTGS2 (0.42) | MAOBRXRARXRBNR4A2GPR174 | |
| SCHEMBL8559262 | 0.91 | NR4A2 (0.40) | MAOBRXRARXRBNR4A2GPR174 | |
| SCHEMBL8556992 | 0.91 | PTGS1 (0.40) | MAOBRXRARXRBNR4A2GPR174 | |
| SCHEMBL8558066 | 0.91 | NR4A2 (0.40) | MAOBRXRARXRBNR4A2GPR174 | |
| SCHEMBL8560532 | 0.88 | RXRA (0.46) | RXRARXRBNR4A2ALDH1A1HPGD | |
| SCHEMBL8555499 | 0.88 | RXRA (0.49) | MAOBRXRARXRBNR4A2NPC1 | |
| SCHEMBL8560360 | 0.87 | RXRA (0.44) | MAOBRXRARXRBNR4A2ALDH1A1 | |
| SCHEMBL8556768 | 0.87 | NR4A2 (0.45) | RXRARXRBNR4A2ALDH1A1LMNA | |
| SCHEMBL8558684 | 0.86 | RXRA (0.46) | MAOBRXRARXRBNR4A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |