Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.46 |
| ▸ | RXRB | P28702 | 6/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 6/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556768 | 0.92 | NR4A2 (0.45) | RXRARXRBNR4A2RXRGALDH1A1 | |
| SCHEMBL8560576 | 0.91 | RXRA (0.46) | RXRARXRBNR4A2RXRGALDH1A1 | |
| SCHEMBL8560360 | 0.90 | RXRA (0.44) | RXRARXRBNR4A2RXRGALDH1A1 | |
| SCHEMBL8555226 | 0.89 | RXRA (0.46) | RXRARXRBNR4A2RXRGALDH1A1 | |
| SCHEMBL8561129 | 0.89 | PTGS2 (0.44) | RXRARXRBNR4A2RXRGPTGS1 | |
| SCHEMBL8553402 | 0.88 | SCN9A (0.44) | RXRARXRBNR4A2F10CYP3A4 | |
| SCHEMBL8561401 | 0.88 | MAOB (0.41) | RXRARXRBNR4A2RXRGALDH1A1 | |
| SCHEMBL8555499 | 0.88 | RXRA (0.49) | RXRARXRBNR4A2RXRGF10 | |
| SCHEMBL8558684 | 0.86 | RXRA (0.46) | RXRARXRBNR4A2RXRGALDH1A1 | |
| SCHEMBL8554839 | 0.86 | RXRA (0.38) | RXRARXRBNR4A2RXRGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |