Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.40 |
| ▸ | RXRB | P28702 | 6/20 | 0.40 |
| ▸ | RXRG | P48443 | 4/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557001 | 0.92 | RXRA (0.40) | RXRARXRBRXRGF10ADORA2A | |
| SCHEMBL8555605 | 0.92 | RXRA (0.44) | RXRARXRBRXRGNR4A2ALOX5AP | |
| SCHEMBL8556768 | 0.89 | NR4A2 (0.45) | RXRARXRBRXRGNR4A2FAAH | |
| SCHEMBL8561129 | 0.88 | PTGS2 (0.44) | RXRARXRBRXRGNR4A2PTGS2 | |
| SCHEMBL8557992 | 0.88 | ALOX5AP (0.41) | RXRARXRBRXRGF10NR4A2 | |
| SCHEMBL8555499 | 0.88 | RXRA (0.49) | RXRARXRBRXRGF10NR4A2 | |
| SCHEMBL8555143 | 0.88 | RXRA (0.49) | RXRARXRBRXRGF10NR4A2 | |
| SCHEMBL8557215 | 0.87 | PTGS2 (0.42) | RXRARXRBF10NR4A2ALOX5AP | |
| SCHEMBL8560601 | 0.85 | ALOX5AP (0.41) | ADORA2AADORA1ALOX5APFEN1LTB4R | |
| SCHEMBL8555192 | 0.85 | POLB (0.37) | ALOX5APFEN1LTB4RLTB4R2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |