Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | APP | P05067 | 4/20 | 0.35 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | ARAF | P10398 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MYOC | Q99972 | 1/20 | 0.35 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382993 | 0.81 | TGM2 (0.44) | TGM2CES1LRRK2MAPTAPP | |
| SCHEMBL8556891 | 0.78 | RET (0.37) | TGM2CES1MAPTPIM1CSNK2A1 | |
| SCHEMBL8555842 | 0.78 | KMT2A (0.39) | TGM2CES1LRRK2MAPTMEN1 | |
| SCHEMBL5760370 | 0.78 | ROS1 (0.46) | TGM2CES1LRRK2MAPTMEN1 | |
| SCHEMBL2429783 | 0.75 | JUN (0.44) | NFKB1KMT2ATDP2PARP1 | |
| SCHEMBL8558339 | 0.75 | PDPK1 (0.45) | LRRK2EGFRCDK1KDRGSK3A | |
| SCHEMBL8555149 | 0.74 | CA1 (0.39) | TGM2CES1HSD17B10TDP1PDE3B | |
| SCHEMBL2334055 | 0.73 | EPHX2 (0.41) | TGM2CES1 | |
| SCHEMBL554552 | 0.72 | MAPT (0.46) | LRRK2MAPTPLK4PIM1MEN1 | |
| SCHEMBL8121209 | 0.70 | GRIN2D (0.35) | LRRK2MAPTPLK4MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |