Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.38 |
| ▸ | KDR | P35968 | 8/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555812 | 0.75 | TGM2 (0.50) | KDRLRRK2EGFRNOS1GSK3B | |
| SCHEMBL5760370 | 0.75 | ROS1 (0.46) | PDPK1PDGFRBLRRK2CDK5CCNB2 | |
| SCHEMBL8556891 | 0.75 | RET (0.37) | PDPK1CHEK1 | |
| SCHEMBL8555842 | 0.75 | KMT2A (0.39) | LRRK2CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL2429783 | 0.72 | JUN (0.44) | NOTUM | |
| SCHEMBL30639075 | 0.71 | TGM2 (0.55) | PDPK1LRRK2GSK3BGSK3ACDK5 | |
| SCHEMBL2498450 | 0.71 | TGM2 (0.55) | PDPK1LRRK2GSK3BGSK3ACDK5 | |
| SCHEMBL8555149 | 0.71 | CA1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL11430847 | 0.70 | TGM2 (0.53) | PDPK1LRRK2GSK3BGSK3ACDK5 | |
| SCHEMBL2334055 | 0.70 | EPHX2 (0.41) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |