Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558072 | 0.82 | PTGS2 (0.46) | MAPTPTGS1PTGS2PTPN2PTPN1 | |
| SCHEMBL8558727 | 0.82 | MAPT (0.45) | MAPTPTGS2PTPN2PTPN1PTPN5 | |
| SCHEMBL8558401 | 0.82 | MAPT (0.45) | MAPTPTGS1PTGS2PTPN2PTPN1 | |
| SCHEMBL8559301 | 0.81 | KMT2A (0.44) | MAPTPTGS2KDM4ERAB9AATM | |
| SCHEMBL8558539 | 0.81 | PTGS2 (0.47) | MAPTPTGS1PTGS2PTPN2PTPN1 | |
| SCHEMBL8556139 | 0.80 | MAPT (0.47) | MAPTPTPN2PTPN1PTPN5HSPD1 | |
| SCHEMBL8557761 | 0.79 | MAPT (0.49) | MAPTPTGS1PTGS2PTPN2PTPN1 | |
| SCHEMBL9026918 | 0.78 | AR (0.45) | MAPTPTPN2PTPN1PTPN5KMT2A | |
| SCHEMBL8560966 | 0.76 | AR (0.48) | MAPTPTPN2PTPN1PTPN5HSPD1 | |
| SCHEMBL8559926 | 0.76 | MAPT (0.47) | MAPTPTGS2HDAC4PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |