Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555819 | 0.81 | MAPT (0.40) | KMT2AMAPTATMKDM4EPTPN2 | |
| SCHEMBL8560329 | 0.79 | PTGS2 (0.52) | KMT2AMAPTKDM4EPTPN2PTPN1 | |
| SCHEMBL8560089 | 0.78 | MAPT (0.58) | KMT2AMAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL8559926 | 0.75 | MAPT (0.47) | KMT2AMAPTLMNAHSD17B10PTPN2 | |
| SCHEMBL8556139 | 0.75 | MAPT (0.47) | KMT2AMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL8558820 | 0.75 | MAPT (0.47) | KMT2AMAPTHSD17B10PTPN2PTPN1 | |
| SCHEMBL8557761 | 0.74 | MAPT (0.49) | KMT2AMAPTLMNAPTPN2PTPN1 | |
| SCHEMBL8560966 | 0.74 | AR (0.48) | KMT2AMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL8558401 | 0.73 | MAPT (0.45) | KMT2AMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL8558727 | 0.73 | MAPT (0.45) | KMT2AMAPTPTPN2PTPN1PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |