Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560249 | 0.83 | HPGD (0.53) | NAMPTRAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8558342 | 0.82 | HPGD (0.48) | NAMPTRAB9ASMN1; SMN2ALDH1A1AVPR1A | |
| SCHEMBL8558207 | 0.82 | AVPR2 (0.60) | NAMPTRAB9ASMN1; SMN2ALDH1A1AVPR1A | |
| SCHEMBL8558857 | 0.80 | HPGD (0.57) | NAMPTRAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7332271 | 0.79 | AVPR1A (0.72) | AVPR1AAVPR2 | |
| SCHEMBL7345049 | 0.78 | TSHR (0.76) | RAB9ASMN1; SMN2ALDH1A1TSHRAVPR1A | |
| SCHEMBL8560873 | 0.78 | ACHE (0.60) | NAMPTRAB9AAVPR1AAVPR2HSD17B3 | |
| SCHEMBL8562598 | 0.78 | PDE4A (0.54) | RAB9ASMN1; SMN2ALDH1A1TSHRAVPR1A | |
| SCHEMBL8562633 | 0.78 | AVPR2 (0.55) | RAB9ASMN1; SMN2AVPR1AAVPR2HPGD | |
| SCHEMBL8563073 | 0.76 | AVPR1A (0.51) | NAMPTAVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |