Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.70 |
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553783 | 0.92 | HTR1A (0.81) | HTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL8871283 | 0.88 | HTR1A (0.69) | HTR1ADRD2DRD3 | |
| SCHEMBL8558887 | 0.87 | HTR1A (0.73) | HTR1ADRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8554084 | 0.87 | HTR1A (0.78) | HTR1ADRD2HTR2ADRD1DRD3 | |
| SCHEMBL8555961 | 0.84 | HTR1A (0.68) | HTR1ADRD2SLC6A4 | |
| SCHEMBL8871306 | 0.81 | HTR1A (0.77) | HTR1ADRD2DRD3 | |
| SCHEMBL11313868 | 0.79 | HTR1A (0.75) | HTR1ADRD2SLC6A4HTR2ADRD1 | |
| SCHEMBL10575993 | 0.79 | HTR1A (0.76) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL8554055 | 0.79 | HTR1A (0.61) | HTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL8554164 | 0.78 | DRD2 (0.69) | HTR1ADRD2SLC6A4HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |