Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 7/20 | 0.37 |
| ▸ | CA2 | P00918 | 7/20 | 0.37 |
| ▸ | CA9 | Q16790 | 5/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | RXRB | P28702 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556716 | 0.96 | NR4A2 (0.38) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8556401 | 0.90 | CYP2C9 (0.40) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8554839 | 0.90 | RXRA (0.38) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8557401 | 0.88 | NR4A2 (0.46) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8559362 | 0.88 | ALOX5AP (0.40) | RXRARXRBALDH1A1MAPTNPC1 | |
| SCHEMBL8556756 | 0.88 | NPC1 (0.39) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8556349 | 0.88 | RXRA (0.38) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8554223 | 0.87 | GPR55 (0.36) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8553420 | 0.86 | MAPT (0.40) | CA12CA1CA2NR4A2RXRA | |
| SCHEMBL8561430 | 0.86 | ALOX5AP (0.40) | NR4A2RXRARXRBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |