Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | RXRB | P28702 | 3/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA6 | P23280 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553816 | 0.96 | MAPT (0.40) | MAPTALDH1A1LMNAGRM2RXRA | |
| SCHEMBL8556401 | 0.90 | CYP2C9 (0.40) | MAPTALDH1A1LMNARXRARXRB | |
| SCHEMBL8554839 | 0.90 | RXRA (0.38) | MAPTALDH1A1RXRARXRBRXRG | |
| SCHEMBL8558684 | 0.88 | RXRA (0.46) | MAPTALDH1A1LMNARXRARXRB | |
| SCHEMBL8559713 | 0.88 | FABP1 (0.38) | MAPTALDH1A1RXRARXRBRXRG | |
| SCHEMBL8561449 | 0.88 | RXRA (0.40) | MAPTALDH1A1LMNARXRARXRB | |
| SCHEMBL8559383 | 0.88 | RXRA (0.47) | MAPTALDH1A1LMNARXRARXRB | |
| SCHEMBL8560882 | 0.87 | MAPT (0.43) | MAPTALDH1A1LMNARXRARXRB | |
| SCHEMBL9025390 | 0.87 | ALDH1A1 (0.41) | MAPTALDH1A1LMNAGRM2RXRA | |
| SCHEMBL8555966 | 0.86 | CA12 (0.37) | MAPTALDH1A1LMNARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |