Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555240 | 0.94 | SLC6A4 (0.55) | ADRA1DSLC6A4HTR1AHTR7KCNH2 | |
| SCHEMBL8558927 | 0.88 | ADRA1D (0.63) | ADRA1DSLC6A4HTR1A | |
| SCHEMBL8556391 | 0.88 | ADRA1D (0.74) | ADRA1DSLC6A4HTR1A | |
| SCHEMBL8555253 | 0.86 | HTR1A (0.62) | ADRA1DSLC6A4HTR1AHTR7 | |
| SCHEMBL8872968 | 0.85 | HTR1A (0.49) | SLC6A4HTR1AHTR7KCNH2 | |
| SCHEMBL8554922 | 0.84 | ADRA1D (0.73) | ADRA1DSLC6A4HTR1A | |
| SCHEMBL8556970 | 0.84 | ADRA1D (0.60) | ADRA1DSLC6A4HTR1A | |
| SCHEMBL8555085 | 0.83 | HTR1A (0.73) | ADRA1DSLC6A4HTR1AHTR7 | |
| SCHEMBL8552976 | 0.83 | HTR1A (0.66) | ADRA1DSLC6A4HTR1AHTR7 | |
| SCHEMBL8557457 | 0.82 | HTR7 (0.65) | ADRA1DSLC6A4HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |