Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559411 | 0.97 | HTR1A (0.61) | ADRA1DSLC6A4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8558927 | 0.96 | ADRA1D (0.63) | ADRA1DSLC6A4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8559641 | 0.94 | CYP1A2 (0.63) | ADRA1DSLC6A4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8559023 | 0.93 | CYP1A2 (0.60) | ADRA1DCYP1A2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL8554847 | 0.91 | CYP1A2 (0.65) | SLC6A4CYP1A2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL8556391 | 0.89 | ADRA1D (0.74) | ADRA1DSLC6A4HTR1A | |
| SCHEMBL7533678 | 0.88 | CYP1A2 (0.61) | ADRA1DSLC6A4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8556284 | 0.86 | HTR1A (0.57) | ADRA1DSLC6A4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8554922 | 0.86 | ADRA1D (0.73) | ADRA1DSLC6A4HTR1A | |
| SCHEMBL8553229 | 0.85 | HTR1A (0.64) | ADRA1DSLC6A4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| CN-1114651-A | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1996-01-10 | — | — | CN | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |