Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552621 | 0.85 | PTGS2 (0.55) | PTGS2PTGS1ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL8796825 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL5597068 | 0.78 | PTGS1 (0.75) | PTGS2PTGS1ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL11601324 | 0.78 | MAPK1 (0.44) | PTGS2ALDH1A1MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL3246495 | 0.77 | PTGS2 (0.50) | PTGS2PTGS1SCD | |
| SCHEMBL19350071 | 0.70 | CTSS (0.46) | PTGS2PTGS1ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL15245084 | 0.69 | SCD (0.65) | PTGS2SCD | |
| SCHEMBL7088050 | 0.68 | PTGS1 (0.66) | PTGS2PTGS1ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL5593896 | 0.68 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL5052857 | 0.67 | PTGS2 (0.74) | PTGS2PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880504-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997027181-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-07-31 | — | — | WO | disclosed |