Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 4/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16605572 | 0.82 | BACE1 (0.42) | KDM1APNMTBACE1 | |
| SCHEMBL8553587 | 0.78 | BACE1 (0.39) | KDM1ABACE1 | |
| Hydrochloric Acid SCHEMBL9179624 | 0.76 | BACE1 (0.38) | KDM1ABACE1 | |
| SCHEMBL16605583 | 0.75 | KDM1A (0.41) | KDM1APNMTBACE1ESR1ESR2 | |
| SCHEMBL8559759 | 0.72 | KDM1A (0.41) | KDM1AHTR2AHTR2CHTR2BPNMT | |
| SCHEMBL8653266 | 0.70 | ADRA2A (0.50) | KDM1AHTR2AHTR2CPNMT | |
| SCHEMBL27680709 | 0.67 | KDM1A (0.43) | KDM1AHTR2AHTR2CHTR2BSRD5A1 | |
| Hydrochloric Acid SCHEMBL9515919 | 0.67 | KDM1A (0.40) | KDM1AHTR2AHTR2CHTR2BPNMT | |
| SCHEMBL2498788 | 0.66 | ESR2 (0.51) | KDM1AHTR2AHTR2CHTR2BSRD5A1 | |
| SCHEMBL15962624 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635497-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them | ADIR (FR) | 1998-05-20 | — | — | EP | disclosed |
| US-5436261-A | Adrenergic agonists | ADIR ET COMPAGNIE (FR) | 1995-07-25 | — | — | US | disclosed |
| EP-0635497-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |