Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 2/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553587 | 0.76 | BACE1 (0.39) | ADRA2AKDM1A | |
| Hydrochloric Acid SCHEMBL9179624 | 0.75 | BACE1 (0.38) | ADRA2AKDM1A | |
| SCHEMBL7918142 | 0.73 | BACE1 (0.33) | — | |
| SCHEMBL8651098 | 0.73 | ADRA2A (0.48) | ADRA2ATAAR1ADRA2BADRA2CADRA1D | |
| SCHEMBL8650675 | 0.73 | LMNA (0.36) | — | |
| SCHEMBL8648724 | 0.72 | ADRA2A (0.47) | ADRA2ATAAR1ADRA2BADRA2CADRA1D | |
| SCHEMBL8649961 | 0.71 | ADRA2A (0.46) | ADRA2ATAAR1ADRA2BADRA2CADRA1D | |
| SCHEMBL8828732 | 0.71 | ADRA2A (0.46) | ADRA2ATAAR1ADRA2BADRA2CADRA1D | |
| SCHEMBL8556494 | 0.70 | KDM1A (0.41) | PNMTKDM1AHTR2AHTR2C | |
| SCHEMBL8620656 | 0.70 | ADRA2A (0.48) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635495-B1 | Benzospiroalkene derivates, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-09-16 | — | — | EP | disclosed |
| US-5648374-A | A2-ADRENERGIC AGONISTS | ADIR ET COMPAGNIE (FR) | 1997-07-15 | — | — | US | disclosed |
| US-5486532-A | ADRENERGIC AGONIST | ADIR ET COMPAGNIE (FR) | 1996-01-23 | — | — | US | disclosed |
| EP-0635495-A2 | Benzospiroalkene derivates, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |