Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560591 | 0.91 | NR4A2 (0.46) | NR4A2CA1CA2CA9CA5A | |
| SCHEMBL8558012 | 0.88 | CA1 (0.44) | NR4A2CA1CA2CA9RXRA | |
| SCHEMBL8555990 | 0.87 | NR4A2 (0.62) | NR4A2CA1CA2CA9RXRA | |
| SCHEMBL7504069 | 0.82 | NR4A2 (0.53) | NR4A2CA1CA2CA9CA5A | |
| SCHEMBL7510938 | 0.82 | NR4A2 (0.53) | NR4A2CA1CA2CA9CA5A | |
| SCHEMBL8555951 | 0.81 | NR4A2 (0.49) | NR4A2RXRARXRBRXRGPTGS1 | |
| SCHEMBL9428384 | 0.81 | NR4A2 (0.69) | NR4A2RXRARXRBRXRGPTGS1 | |
| SCHEMBL8560771 | 0.79 | RXRA (0.55) | NR4A2RXRARXRBRXRGPTGS1 | |
| SCHEMBL8556797 | 0.79 | ALDH1A1 (0.46) | NR4A2CA1CA2CA9RXRA | |
| SCHEMBL8560570 | 0.78 | RXRA (0.53) | NR4A2RXRARXRBRXRGPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |