Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 5/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562598 | 0.84 | PDE4A (0.54) | HSD17B3AVPR2AVPR1ARAB9ASMN1; SMN2 | |
| SCHEMBL8558207 | 0.81 | AVPR2 (0.60) | HSD17B3AVPR2AVPR1ARAB9AKMT2A | |
| SCHEMBL8556917 | 0.81 | ALDH1A1 (0.50) | AVPR2AVPR1AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7352773 | 0.81 | RAB9A (0.48) | AVPR2AVPR1ARAB9AKMT2ANPC1 | |
| SCHEMBL7338770 | 0.80 | AVPR1A (0.67) | AVPR2AVPR1A | |
| SCHEMBL7356848 | 0.79 | AVPR2 (0.69) | AVPR2AVPR1AKMT2AMEN1PDE4A | |
| SCHEMBL7338277 | 0.78 | AVPR2 (0.51) | AVPR2AVPR1A | |
| SCHEMBL8560249 | 0.77 | HPGD (0.53) | HSD17B3AVPR2AVPR1ARAB9AKMT2A | |
| SCHEMBL8558342 | 0.76 | HPGD (0.48) | HSD17B3AVPR2AVPR1ARAB9AKMT2A | |
| SCHEMBL8555952 | 0.75 | NAMPT (0.51) | HSD17B3AVPR2AVPR1ARAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0871630-A1 | 4a,5a,8a,8b-TETRAHYDRO-6H-PYRROLO 3,4':4,5]FURO(3,2-b)PYRIDINE-6,8 7H]-DIONE DERIVATIVES FOR USE IN CONTROLLING ENDOPARASITES AND A METHOD OF PRODUCING SAID DERIVATIVES | BAYER AG (DE) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997014695-A1 | 4a,5a,8a,8b-TETRAHYDRO-6H-PYRROLO[3,4':4,5]FURO(3,2-b)PYRIDINE-6,8[7H]-DIONE DERIVATIVES FOR USE IN CONTROLLING ENDOPARASITES AND A METHOD OF PRODUCING SAID DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-24 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |