Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8471426 | 0.78 | CYP2D6 (0.53) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL8287924 | 0.72 | KMT2A (0.43) | OPRM1SIGMAR1TSHR | |
| SCHEMBL8556730 | 0.69 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL29972822 | 0.69 | SMN1; SMN2 (0.43) | OPRD1OPRK1SIGMAR1ALDH1A1TSHR | |
| SCHEMBL8555156 | 0.68 | SIGMAR1 (0.47) | OPRM1SIGMAR1 | |
| SCHEMBL7435969 | 0.67 | L3MBTL1 (0.51) | ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL23554801 | 0.65 | SMN1; SMN2 (0.50) | SIGMAR1ALDH1A1 | |
| SCHEMBL1749312 | 0.65 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL8555281 | 0.64 | MC4R (0.34) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL11005301 | 0.63 | ALDH1A1 (0.59) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | claimed |