Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561524 | 0.86 | HPGD (0.46) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL8559724 | 0.78 | AVPR2 (0.51) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL6995135 | 0.78 | AVPR2 (0.48) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL8556725 | 0.78 | AVPR2 (0.48) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL8559469 | 0.78 | AVPR2 (0.65) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL8820823 | 0.77 | AVPR2 (0.55) | AVPR2AVPR1A | |
| SCHEMBL8561104 | 0.76 | AVPR2 (0.53) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL8820724 | 0.75 | AVPR2 (0.52) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL7351134 | 0.74 | AVPR2 (0.59) | RAB9ASMN1; SMN2NPC1KMT2AHPGD | |
| SCHEMBL19078674 | 0.74 | RAB9A (0.51) | RAB9ASMN1; SMN2NPC1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047625-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |