Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550682 | 0.89 | DGAT2 (0.44) | DGAT2LMNANPY1R | |
| SCHEMBL8555907 | 0.88 | CHEK2 (0.43) | DGAT2PRMT5 | |
| SCHEMBL8552642 | 0.88 | DGAT2 (0.41) | DGAT2PRMT5L3MBTL1GRIN2BLMNA | |
| SCHEMBL8555463 | 0.87 | GPR119 (0.40) | DGAT2PRMT5NPY1R | |
| SCHEMBL8552606 | 0.86 | DGAT2 (0.43) | DGAT2LMNANPY1R | |
| SCHEMBL8556312 | 0.82 | PRMT5 (0.51) | PRMT5NPY1R | |
| SCHEMBL8555848 | 0.81 | DGAT2 (0.39) | DGAT2PRMT5BCHE | |
| SCHEMBL8552592 | 0.80 | GPR119 (0.39) | DGAT2PRMT5NPY1R | |
| SCHEMBL8553571 | 0.79 | NPY1R (0.45) | PRMT5NPC1RAB9ASMN1; SMN2NPY1R | |
| SCHEMBL7686453 | 0.78 | DGAT2 (0.44) | DGAT2PRMT5BCHENPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871442-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997025041-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |