Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555463 | 0.94 | GPR119 (0.40) | CHEK2DGAT2CYP2C9PRMT5GPR119 | |
| SCHEMBL8555848 | 0.88 | DGAT2 (0.39) | CHEK2DGAT2ALOX5APFEN1CYP2C9 | |
| SCHEMBL8556963 | 0.88 | DGAT2 (0.41) | DGAT2PRMT5 | |
| SCHEMBL8552592 | 0.87 | GPR119 (0.39) | CHEK2DGAT2CYP2C9PRMT5GPR119 | |
| SCHEMBL8550682 | 0.87 | DGAT2 (0.44) | CHEK2DGAT2 | |
| SCHEMBL7686453 | 0.86 | DGAT2 (0.44) | CHEK2DGAT2CYP2C9PRMT5FNTA | |
| SCHEMBL8552606 | 0.86 | DGAT2 (0.43) | CHEK2DGAT2 | |
| Trifluoroacetic Acid SCHEMBL8552693 | 0.83 | CHEK2 (0.40) | CHEK2DGAT2ALOX5APFEN1PRMT5 | |
| SCHEMBL8557780 | 0.83 | GPR119 (0.44) | CHEK2DGAT2PRMT5GPR119 | |
| SCHEMBL8553086 | 0.81 | GPR119 (0.44) | CHEK2DGAT2PRMT5GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871442-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997025041-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |