Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557536 | 0.96 | MTNR1A (0.57) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 | |
| SCHEMBL9828299 | 0.89 | HTR1D (0.67) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 | |
| SCHEMBL9698903 | 0.88 | MTNR1A (0.56) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 | |
| SCHEMBL9697617 | 0.86 | HTR1D (0.57) | MTNR1AMTNR1BHTR1ACYP1A2KMT2A | |
| SCHEMBL8538858 | 0.85 | CYP1A2 (0.56) | MTNR1AMTNR1BHTR1ACYP1A2MPO | |
| SCHEMBL8540815 | 0.84 | FAAH (0.59) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 | |
| SCHEMBL8555709 | 0.83 | SLC6A4 (0.69) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 | |
| SCHEMBL10648645 | 0.81 | MTNR1A (0.48) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 | |
| SCHEMBL8557448 | 0.81 | GPR84 (0.62) | MTNR1AMTNR1BHTR1ACYP1A2KMT2A | |
| SCHEMBL8558403 | 0.79 | SLC6A4 (0.71) | MTNR1AMTNR1BHTR1ACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |