Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537746 | 0.85 | FAAH (0.54) | FAAHTRPV1MTNR1AMTNR1BHTR1A | |
| SCHEMBL9261940 | 0.84 | KMT2A (0.57) | TRPV1KMT2AHSD17B10MEN1RAB9A | |
| SCHEMBL8557152 | 0.84 | MTNR1A (0.56) | MTNR1AMTNR1BKDM4EHTR1AKMT2A | |
| SCHEMBL8539238 | 0.82 | FAAH (0.51) | FAAHTRPV1MTNR1AMTNR1BHTR1A | |
| SCHEMBL9828299 | 0.82 | HTR1D (0.67) | MTNR1AMTNR1BKDM4EHTR1AKMT2A | |
| SCHEMBL8540082 | 0.82 | HTR2A (0.53) | FAAHTRPV1MTNR1AMTNR1BHTR1A | |
| SCHEMBL9698973 | 0.82 | FAAH (0.57) | FAAHTRPV1MTNR1AMTNR1BLTA4H | |
| SCHEMBL8557536 | 0.80 | MTNR1A (0.57) | MTNR1AMTNR1BKDM4EHTR1AKMT2A | |
| SCHEMBL9697617 | 0.80 | HTR1D (0.57) | MTNR1AMTNR1BKDM4EHTR1AKMT2A | |
| SCHEMBL8544427 | 0.80 | ADRA2A (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496222-B1 | Indole derivatives | MERCK PATENT GMBH (DE) | 1998-09-09 | — | — | EP | disclosed |
| EP-0496222-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |